DynaChrom Single-Use Chromatography System
The DynaChrom system provides a complete, single-use solution for chromatographic purification—a principal unit operation in downstream bioprocessing of recombinant proteins such as monoclonal antibodies and viral vector production. Pre-engineered system options and modular-flow kit designs allow for selection of tools and technology suitable for a broad range of applications. The DynaChrom system can be used for multiple chromatography steps and, combined with the automation package, provides the platform necessary for consistent, high-performing purification.
KEY FEATURES
Wide, operational flow ranges are available from 1 L/hr to 1,980 L/hr enabled by pump and fluid transfer assembly combinations: 1/4 in., 3/8 in.*, 1/2 in.*, and 3/4 in. sizes with a maximum operating pressure rating of 4 bars. This offering provides a configurable system with operational flexibility to support the gamut of scales needed from process development to manufacturing.
The hardware, software, and single-use consumables of the DynaChrom system meet the demands of modern downstream bioprocessing with isocratic and gradient elution support, as well as inline dilution capability. The system can be configured for bind-elute, flow-through, and other modes of operation. (See the Software section for details.)
The zero dead leg with ring flush valve design eliminates residual fluid in the line sets because the previous phase liquids are instantly flushed at the start of a new phase. This can result in less buffer use, improved peak resolution, and increased product yield.
The novel, single-use valve manifold removes limitations caused by pinch valves or clamshell-liner designs. Scalable design of the valve block and locking mechanism allows for easy flow path scaling with the various fluid transfer assemblies. The valve manifold also provides easy and precise transfer assembly installation enabling safe operation and quick turnaround time for process operation.
The DynaChrom system is designed to be column-agnostic so it can work with any end user–selected membrane or resin column (prepacked or self-packed) that adheres to the design specification of the system. The system also has column upflow and downflow capability. Column size recommendations to match the flow rates and line set sizes are provided in the Specifications section. We can also provide consultation for the selection of our chromatography purification products.
Ergonomic, space-saving design of the system provides ease of access for system operation and maintenance, including line-set installation and operator interface for monitoring and control.
Thermo Scientific™ TruChrom™ Automation Software, powered by the Emerson™ DeltaV™ Distributed Control System, provides the ability to leverage existing DeltaV network infrastructure and allows ease of tech transfer, data integration, and data storage. (DeltaV v14 is required for other DeltaV versions. Please consult with our technical sales support.)
The simplified recipe structure of TruChrom software provides an enhanced user experience. Configurable user access, an audit trail, and batch reporting are available as standard features.