Thermo Scientific™ HyPerforma™ enhanced Single-Use Fermentor (eS.U.F.)
The HyPerforma S.U.F. and Thermo Scientific™ BioProcess Container (BPC) system uses traditional stainless steel fermentor engineering principles to meet the high demands of industrial microbiology with efficient mass transfer, mixing, and temperature control. Thermo Fisher Scientific offers stand-alone and collective workflow solutions, incorporating flexible or rigid containment with S.U.F. technologies to support microbial fermentation. Consistency in specification and performance across size builds confidence in quality and creates efficacy during the scale-up process.
KEY FEATURES
The HyPerforma S.U.F. systems offer:
30 L and 300 L working volume with a 5:1 turndown ratio
Vertically centered, top-driven impeller locations for powerful mixing
Consistent scalability from process development through production
Single-use sensors: pH, DO, temperature, foam, pressure, and biomass
High-flow exhaust filters
Four 1/8 in. (ID) feed, two 3/8 in. (ID) fill, 1/2 in. drain, and sparge filter line set(s)
The HyPerforma eS.U.F. features:
35% increase in jacketed surface area for the 300 L size
4x higher oxygen delivery in 30 L and 300 L due to a larger, more powerful impeller design
Oxygen delivery as good as or better than stainless steel fermentors
Redesigned BPC with three enhanced parabolic turbine impellers
Powerful and efficient
The HyPerforma S.U.F. and BPC system is designed to deliver optimal growth of microorganisms through high gas flow rates, powerful agitation, and efficient cooling. Purpose-built to match the process demands of traditional clean-in-place and steam-in-place (CIP/SIP) stainless steel fermentors, the S.U.F. design makes the transition from traditional to single-use fermentors straightforward and easy.
The HyPerforma S.U.F. was created as a closed system that facilitates the growth of microorganisms, equipped with a sterile holding tank, impeller, coolant system, control panel, sparging capability, and input and output channel. This design enables researchers to monitor specific maintenance parameters including temperature, oxygenation level, agitation, speed, and the need for additional nutrient supplements or anti-foam additives with limited risk of impact to the bulk media broth.
The HyPerforma S.U.F. and BPC system offers:
Powerful mixing from a top-driven shaft with three Rushton impellers in a baffled vessel
Controlled, flexible delivery of air and oxygen through drilled-hole spargers
Reliable off-gassing with a proprietary exhaust management system
Increased cooling capacity with a 3:1 aspect ratio that maximizes surface area
Automated foam control to reduce the risk of excess foam buildup
Robust BPC design with integrated single-use sensor technology for continuous assessment of pH, DO, temperature, foam, and pressure