DynaDrive Single-Use Bioreactor
Next-generation impeller drive train brings flexibility and economy of scale to single-use bioreactor technology
The DynaDrive S.U.B. can decrease the cost of production by 25% through a reduction in equipment, materials, consumables, and labor. The increased reactor size lowers the number of production batches required for a given volumetric demand. Beyond its value when compared to other single-use reactors, the DynaDrive S.U.B. expands the range for which single-use technologies (SUT) are a legitimate alternative to traditional stainless-steel bioreactor platforms.
Economic modeling has shown it provides both a lower average cost per gram and net present cost of investment up to scales of 4,200 kilograms per year of production. It is one of the largest single-use offerings in the market and is backed by the Thermo Fisher Scientific reputation for excellence. With a long history of maintaining a trusted bioreactor supply partnership measured by validation success, our technical professionals and continued support provide the reliability and flexibility needed to meet your needs, regardless of scale.
High performance that is predictable, flexible, and multipurpose
A scalable design providing efficiency in manufacturing with the ability to transfer processes from 50 L up to 5,000 L Performance enhancements in mixing, power input per volume, and optimized kLa to accommodate high-density cell culture processes with 0.1 vvm flow Scalable and streamlined data flow, with digital scaling tools and robust data packages with integrated hardware and an automation solution: Thermo Scientific™ TruBio™ Bioprocess Control Software powered by the Emerson™ DeltaV™ Distributed Control Platform Hardware and Thermo Scientific™ BioProcess Container (BPC) design optimization for perfusion cell culture process capability
Cost-effective drug substance manufacturing
Economies of scale with large-scale production, efficient labor usage, reduced vessel count, and optimized >10:1 seed train turndown, decrease the cost of production by 25% Leveraging higher in-vessel turndown ratios to run multiple stages in a single vessel, reducing the number of BPCs loaded and unloaded, as well as the number of vessels needed in the overall facility
Improved sustainability
Reduced consumable waste by reducing waste per volume and vessel count
Reliability and risk reduction
Robust and ergonomic BPC design for ease of loading with install assist hardware, and daily operations with reduced tubing connections required BPC film and components tested for leachable and extractable (L&E) evaluation according to BioPhorum Operations Group (BPOG) guidelines Hardware that is designed to meet 21 CFR 820 cGMP requirement